An RpoB Mutation Confers Dual Heteroresistance to Daptomycin and Vancomycin in Staphylococcus aureus
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منابع مشابه
An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
We have previously reported the establishment of a Staphylococcus aureus laboratory strain, 10 3d1, having reduced susceptibility to daptomycin and heterogeneous vancomycin-intermediate S. aureus (VISA) phenotype. The strain was generated in vitro by serial daptomycin selection (Camargo, I. L., H. M. Neoh, L. Cui, and K. Hiramatsu, Antimicrob. Agents Chemother. 52:4289-4299, 2008). Here we expl...
متن کاملVancomycin heteroresistance and methicillin-resistant Staphylococcus aureus.
Heteroresistance refers to the presence, within a larger population of fully antimicrobial-susceptible microorganisms, of subpopulations with lesser susceptibility. This phenomenon has been described in a wide range of microorganisms, but much recent attention has been directed toward its expression in Staphylococcus aureus. Although it has long been known that resistance to methicillin is char...
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1. Denes E, Magy L, Pradeau K, Alain S, Weinbreck P, Ranger-Rogez S. Successful treatment of human herpesvirus type 6 encephalomyelitis in immunocompetent patient [letter]. Emerg Infect Dis. 2004;10:729–31. 2. Soto-Hernandez JL. Human herpesvirus 6 encephalomyelitis [letter]. Emerg Infect Dis. 2004;10:1700–1. 3. Yoshihara S, Kato R, Inoue T, Miyagawa H, Sashihara J, Kawakami M, et al. Successfu...
متن کاملReduced sensitivity of staphylococcus aureus to vancomycin
Introduction: Staphylococcus aureus is one of the most common causes of infections in hospitals and vancomycin is used for the treatment of methicillin resistant S, aureus infections. Therefore, imergence of Staphylococcus aureus with reduced sensitivity to vancomycin is a serious problem. The aim of this study was to investigate the prevalence of Staphylococcus aureus with reduced suscep...
متن کاملVancomycin and daptomycin minimum inhibitory concentration distribution and occurrence of heteroresistance among methicillin-resistant Staphylococcus aureus blood isolates in Turkey
BACKGROUND The aim of this study was to determine the distribution of vancomycin and daptomycin MICs among methicillin-resistant Staphylococcus aureus (MRSA) blood isolates, the prevalence of heterogeneous vancomycin-intermediate S. aureus (hVISA) and the relationship between hVISA and vancomycin MIC values. METHODS A total of 175 MRSA blood isolates were collected from seven university hospi...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2010
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00437-10